The impact of maximum markup regulation on prices

Markup regulation is a common yet understudied type of regulation. We analyze the repeal of maximum wholesale and retail markup regulation in an oligopolistic and vertically non-integrated market. By comparing the prices of products affected by regulation before and after the policy change and using unregulated products as a control group, we find that abolishing regulation led to a significant decrease in both retail and wholesale prices. The results provide indirect but consistent evidence that markup ceilings provided a focal point for collusion among wholesalers

Interrogating the Evolutionary Paradox of Schizophrenia: A Novel Framework and Evidence Supporting Recent Negative Selection of Schizophrenia Risk Alleles

Schizophrenia is a psychiatric disorder with a worldwide prevalence of ∼1%. The high heritability and reduced fertility among schizophrenia patients have raised an evolutionary paradox: why has negative selection not eliminated schizophrenia associated alleles during evolution? To address this question, we examined evolutionary markers, known as modern-human-specific (MD) sites and archaic-human-specific sites, using existing genome-wide association study (GWAS) data from 34,241 individuals with schizophrenia and 45,604 healthy controls included in the Psychiatric Genomics Consortium (PGC). By testing the distribution of schizophrenia single nucleotide polymorphisms (SNPs) with risk and protective effects in the human-specific sites, we observed a negative selection of risk alleles for schizophrenia in modern humans relative to archaic humans (e.g., Neanderthal and Denisovans). Such findings indicate that risk alleles of schizophrenia have been gradually removed from the modern human genome due to negative selection pressure. This novel evidence contributes to our understanding of the genetic origins of schizophrenia

State officials in the themes of Opsikion, the Anatolikoi and the Kibyrraiotai: new and recently revisited sigillographic evidence.

The aim of the project entitled “Towards an institutional and social history of Byzantine Asia Minor on the evidence of seals and other sources (7th - 13th centuries)” (abbreviated as SigCorpByzAMthemes; project’s code 4492) was to look afresh at the institutional and social history of Byzantine Asia Minor using as main research tool reliable and well-dated prosopographic lists of all the state officials once active in the three earliest Asia Minor themes: the Opsikion, the Anatolikoi and the Kibyrraiotai. The compilation of these prosopographic lists was based mostly, as was to be expected, on sigillographic evidence, duly complemented by relevant references in literary and other non-sigillographic sources

A set of ontologies to drive tools for the control of vector-borne diseases

We are developing a set of ontologies that deal with vector-borne diseases and the arthropod vectors that transmit them. For practical reasons (application priorities), we initiated this project with an ontology of insecticide resistance followed by a series of ontologies that describe malaria as well as physiological processes of mosquitoes that are relevant to, and involved in, disease transmission. These will be expanded to encompass other vector-borne diseases as well as non-mosquito vectors. The aim of the whole undertaking, which is worked out in the frame of the international IDO (Infectious Disease Ontology) project, is to provide the community with a set of ontological tools that can be used both in the development of specific databases and, most importantly, in the construction of decision support systems to control these diseases

MIRO and IRbase: IT Tools for the Epidemiological Monitoring of Insecticide Resistance in Mosquito Disease Vectors

It is a historical fact that a successful campaign against vector populations is one of the prerequisites for effectively fighting and eventually eradicating arthropod-borne diseases, be that in an epidemic or, even more so, in endemic cases. Based mostly on the use of insecticides and environmental management, vector control is now increasingly hampered by the occurrence of insecticide resistance that manifests itself, and spreads rapidly, briefly after the introduction of a (novel) chemical substance. We make use here of a specially built ontology, MIRO, to drive a new database, IRbase, dedicated to storing data on the occurrence of insecticide resistance in mosquito populations worldwide. The ontological approach to the design of databases offers the great advantage that these can be searched in an efficient way. Moreover, it also provides for an increased interoperability of present and future epidemiological tools. IRbase is now being populated by both older data from the literature and data recently collected from field

Secure Precise Clock Synchronization for Interconnected Body Area Networks

Secure time synchronization is a paramount service for wireless sensor networks (WSNs) constituted by multiple interconnected body area networks (BANs). We propose a novel approach to securely and efficiently synchronize nodes at BAN level and/or WSN level. Each BAN develops its own notion of time. To this effect, the nodes of a BAN synchronize with their BAN controller node. Moreover, controller nodes of different BANs cooperate to agree on a WSN global and/or to transfer UTC time. To reduce the number of exchanged synchronization messages, we use an environmental-aware time prediction algorithm. The performance analysis in this paper shows that our approach exhibits very advanced security, accuracy, precision, and low-energy trade-off. For comparable precision, our proposal outstands related clock synchronization protocols in energy efficiency and risk of attacks. These results are based on computations

Dermoid Cysts of the Floor of the Mouth: Two Case Reports

Dermoid cysts in the floor of the mouth may be congenital or acquired. The congenital form, according to the main theory, originates from embryonic cells of the 1st and 2nd branchial arch. The acquired form may be due to traumatic or iatrogenic causes and as a result of the occlusion of a sebaceous gland duct. Its occurrence is less and is estimated to be from 1.6 to 6.4% of the dermoid cysts of the body in adults and 0.29% of the head and neck tumors occurring in children. They may also be classified as anatomical and histological. Anatomically, they are divided into median genioglossal, median geniohyoid, and lateral cysts, while histologically they are divided into epidermoid, dermoid cysts and teratomas. Clinically, a distinction between supra and inferior type as well as between central and lateral type is proposed in relation to themylohyoidmuscle and themidline, respectively. Histologically, an estimation of dermoid, epidermoid, and teratoid cysts is reported. Enucleation via intraoral and/or extraoral approach is the method of treatment. Two case reports of dermoid cysts in the floor of the mouth are presented in this paper, and an evaluation with regard to pathology, clinical findings, differential diagnosis, and treatment is discussed

Edge-based Runtime Verification for the Internet of Things

Complex distributed systems such as the ones induced by Internet of Things (IoT) deployments, are expected to operate in compliance to their requirements. This can be checked by inspecting events flowing throughout the system, typically originating from end-devices and reflecting arbitrary actions, changes in state or sensing. Such events typically reflect the behavior of the overall IoT system – they may indicate executions which satisfy or violate its requirements. This article presents a service-based software architecture and technical framework supporting runtime verification for widely deployed, volatile IoT systems. At the lowest level, systems we consider are comprised of resource-constrained devices connected over wide area networks generating events. In our approach, monitors are deployed on edge components, receiving events originating from end-devices or other edge nodes. Temporal logic properties expressing desired requirements are then evaluated on each edge monitor in a runtime fashion. The system exhibits decentralization since evaluation occurs locally on edge nodes, and verdicts possibly affecting satisfaction of properties on other edge nodes are propagated accordingly. This reduces dependence on cloud infrastructures for IoT data collection and centralized processing. We illustrate how specification and runtime verification can be achieved in practice on a characteristic case study of smart parking. Finally, we demonstrate the feasibility of our design over a testbed instantiation, whereupon we evaluate performance and capacity limits of different hardware classes under monitoring workloads of varying intensity using state-of-the-art LPWAN technology

Modulation of Brain Resting-State Networks by Sad Mood Induction

BACKGROUND: There is growing interest in the nature of slow variations of the blood oxygen level-dependent (BOLD) signal observed in functional MRI resting-state studies. In humans, these slow BOLD variations are thought to reflect an underlying or intrinsic form of brain functional connectivity in discrete neuroanatomical systems. While these 'resting-state networks' may be relatively enduring phenomena, other evidence suggest that dynamic changes in their functional connectivity may also emerge depending on the brain state of subjects during scanning. METHODOLOGY/PRINCIPAL FINDINGS: In this study, we examined healthy subjects (n = 24) with a mood induction paradigm during two continuous fMRI recordings to assess the effects of a change in self-generated mood state (neutral to sad) on the functional connectivity of these resting-state networks (n = 24). Using independent component analysis, we identified five networks that were common to both experimental states, each showing dominant signal fluctuations in the very low frequency domain (approximately 0.04 Hz). Between the two states, we observed apparent increases and decreases in the overall functional connectivity of these networks. Primary findings included increased connectivity strength of a paralimbic network involving the dorsal anterior cingulate and anterior insula cortices with subjects' increasing sadness and decreased functional connectivity of the 'default mode network'. CONCLUSIONS/SIGNIFICANCE: These findings support recent studies that suggest the functional connectivity of certain resting-state networks may, in part, reflect a dynamic image of the current brain state. In our study, this was linked to changes in subjective mood